The body often tends to break down at times, even with the specialized search-and-destroy army. Antibodies are major players when it comes to fighting against disease in the body. The Glucose-regulated protein 94, always abbreviated as (GRP94), is an endoplasmic reticulum (ER)-a resident member of the heat shock protein 90 (HSP90) family. They are essential in certain physiological conditions, such as the regulation of biological functions. Glucose-regulated protein 94 (GRP94) also plays a major role in chaperoning cellular 9riteins in the ER lumen. When they do this, they help with calcium homeostasis maintenance, including the modulation of how the immune system works.
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Benefits of GRP94 antibody
Different reports have shown the roles and functionality, including the relevance of Glucose-regulated protein 94 (GRP94) overexpression in various cancer progression. Apart from its physiological and pathophysiological roles in normal cancer cells, Glucose-regulated protein 94 (GRP94) offer a wide range of benefits to researchers, such as
- They are useful for providing great results, especially for small and poor immunogenic antigens
- They can help in recognizing an additional epitope
- There is a closeness between the human antibody and rat antibody Fc
The need for Glucose-regulated protein 94 (GRP94)
One of the most deadly diseases globally is Cancer and have been responsible for a large number of deaths coming after cardiovascular disease. Generally, it has not shown any sign of coming down. The International Agency has revealed for Research on Cancer has revealed that there were about 19.3 million fresh cancer cases, including 10 million deaths the previous year.
Many years ago, science and technology provided remarkable development, including high throughput screening, design of various drugs, state-of-the-art technology using various forms of modern biology. As a result, this has helped in discovering and improving drugs production against different types of cancers. While one of the conventional means of fighting cancer is through chemotherapy, it is very unfortunate that they concomitantly target normal cells. These include bone marrow, hair follicles, including the digestive tract, which affects the body system entirely. Overcoming these setbacks of cancer therapies has seen researchers target monoclonal antibodies such as grp94 antibody therapy for targeting selective elimination of cancer cells.
The Glucose-regulated protein 94 (GRP94) is a kind of immunotherapy that uses monoclonal antibodies for binding to a certain target antigen. Therefore, Glucose-regulated protein 94 (GRP94) plays an important role in relevance to Cancer for clarifying its pathological metastasis and progression. Since Glucose-regulated protein 94 (GRP94) plays an important role in combating various diseases, including Cancer, researchers have taken time to make it readily available as a product.
About Glucose-regulated protein 94 (GRP94)target information
Glucose-regulated protein 94 (GRP94) is an endoplasmic reticulum (ER)-a resident member of the heat shock protein 90 (HSP90) family, a paralog of cytosolic HSP90. Glucose-regulated protein 94 (GRP94) is an 803 amino acid protein. It belongs to the heat shock protein, 90 families. Glucose-regulated protein 94 (GRP94) functions as a molecular chaperone that works to process and move secreted proteins from one place to the other. They carry out a major function in innate, including immunity acquisition, cross-priming, production of Ab, and lots more. Furthermore, Glucose-regulated protein 94 (GRP94) acts as a potential marker in breast cancer. A study of the current status of Glucose-regulated protein 94 (GRP94)-targetting inhibitors will help provide clues into unmet medical needs for monoclonal antibody therapy.
Applications of Glucose-regulated protein 94 (GRP94) as a product
Glucose-regulated protein 94 (GRP94) have various application. Some of these applications include
Western Blot (WB): The Glucose-regulated protein 94 (GRP94) under the Western Blot targets dog, hamsters, humans, rabbits, insects, mice, chickens, dogs, bacteria, and more. Other applications of the Glucose-regulated protein 94 (GRP94)include immunohistochemistry (Paraffin) (IHC) (P), immunocytochemistry (ICc/IF), immunoprecipitation (IP).
Preparation
The Glucose-regulated protein 94 is produced in rabbits immunized with a synthetic peptide that corresponds to the center region of the Mouse HSP90B1 and purified by antigen affinity chromatography.
Storage
To properly store the Glucose-regulated protein 94, it is best to store at t 2℃-8℃ for four weeks without detectable loss of activity. Antibody products are stable and can stay up to 52 weeks starting from the date of purchase at a storage temperature of -20℃ to -80℃. They usually last for a longer period because they do not contain any preservatives. It is also important to avoid repeated freeze-thaw cycles.
Product shipping
Shipping this antibody is carried out at ambient temperature as a liquid solution. When delivered, you should keep or store them immediately at the above-recommended temperature for long-term use and effectiveness.
Conclusion
There is a mixture of multiple and heterogeneous clones of cells tumors without the same characteristics or features. Even with the various development of therapeutic agents for cancer therapy in the past decades, such as minor chemical inhibitors and mAbs, there have been major setbacks. These setbacks include drug resistance which has been one of the factors hindering better clinical results.
However, a wide range of reports has suggested that Glucose-regulated protein 94 as a prognostic marker carries out an important function in the aspect of cancer cell progression and metastasis. Although more effort has been channeled towards the development of small molecules that inhibit Glucose-regulated protein 94 in Cancer selectively, however, many studies came to a halt as a result of side effects. Some of these negative effects include hepatotoxicity caused by off-target effects in some clinical trials.